Best Compounded Semaglutide May 2026

Six telehealth programs ranked by verified price, conversion data, and format flexibility — with the post-April 2026 FDA context built in.

Updated May 6, 2026·By Chad Simpson·All pricing live-crawled from provider sites

The Quick Take

Best Overall: TMates — $158/mo on the 12-month plan, same price all doses, 6.43% Katalys-verified conversion rate.
Best Entry-Tier: Strut Health — $99/mo oral semaglutide auto-refill, lowest verified GLP-1 entry price in our stack.
Best No-Commitment: System Labs — $179/mo with no long-term contract, plus longevity peptide stack.
Best First Month: Embody — $149 first month with Spring Forward $200 off, then flat $299/mo refills.

TMates

Best Overall

#1 highest-EPC GLP-1 program in our verified Katalys stack

TMates wins on three fronts: the lowest 12-month price in our verified stack ($158/mo for semaglutide on a $1,900 annual plan), same-price-all-doses pricing that eliminates titration upcharges, and a 6.43% Katalys-verified conversion rate that beats every other program we track. Available in injectable AND oral drop formats at the same price.

Pricing

Verified May 6, 2026

1 month: $249
3 months: $650 ($217/mo, save 13%)
6 months: $1,050 ($175/mo, save 30%)
12 months: $1,900 ($158/mo, save 37%)

Best For

Shoppers committing 6+ months who want the lowest verified per-month cost and access to NAD+, TRT, ED, and hair loss treatment from the same provider.

Pros

Lowest verified 12-month per-month price ($158/mo)
Same price across all doses (sema 0.25–2.4mg) — no titration upcharge
Injectable + oral drop formats at the same price
Multi-vertical: GLP-1, NAD+, TRT, ED, hair
6.43% conversion rate, 2,400+ patients (Katalys May 2026)

Trade-offs

·Lowest pricing requires upfront payment ($1,900 for the 12-month plan)
·Compounded only — no branded Wegovy/Ozempic

Visit TMates Read Full Review

Strut Health

Best Entry-Tier

Lowest entry-tier oral semaglutide in our verified stack

Strut Health offers ORAL compounded semaglutide on auto-refill starting at $99/mo — the lowest verified GLP-1 entry-tier price in our entire Katalys stack. The platform uses async no-video physician review (≤1 business day turnaround), free shipping, free follow-up care, and is LegitScript + HIPAA compliant. Note: oral-only — no injectable.

Pricing

Verified May 6, 2026

Oral Semaglutide auto-refill: $99/mo (save 21%)
Oral Tirzepatide auto-refill: $199/mo (save 17%)
No long-term commitment required

Best For

Cost-conscious patients who want the lowest entry-tier monthly price and are open to oral semaglutide. Multi-condition patients (hair, skin, sexual health) who want one async no-video provider.

Pros

$99/mo auto-refill — lowest verified entry-tier price
No video visit required — async physician review ≤1 business day
7.12% conversion rate (highest CR in our active stack — Katalys May 2026)
Multi-vertical: GLP-1, hair (finasteride/dutasteride), skin, ED, herpes
Free shipping, free follow-up care, cancel anytime, LegitScript accredited

Trade-offs

·Oral-only — no injectable semaglutide on public catalog
·AK excluded (Alaska state restriction)
·Oral compounded GLP-1 efficacy data less robust than injectable

Visit Strut Health Read Full Review

System Labs

Best No-Commitment

Lowest no-commitment monthly price ($179/mo)

System Labs offers compounded GLP-1 at $179/mo with no long-term commitment — the cheapest no-commitment GLP-1 entry in the active Katalys stack. The platform also covers a broader longevity stack: NAD+ ($79 first month), B-12 / MIC, and sermorelin (oral or injectable). Best fit for biohackers who want GLP-1 plus adjacent peptides.

Pricing

Verified May 6, 2026

Compounded GLP-1/GIP: $179/mo (no commitment)
NAD+: $79 first month, $149/mo ongoing
B-12 / MIC+B12: $89/mo
Sermorelin (oral): $79 first month

Best For

Cost-conscious buyers wanting GLP-1 with no commitment, plus access to longevity peptides (NAD+, B-12, sermorelin) under one provider.

Pros

$179/mo — lowest no-commitment GLP-1 entry in stack
Adjacent-peptide cluster: NAD+, B-12, sermorelin (oral + injectable)
First-month discounts across the board
No long-term commitments on any program

Trade-offs

·Lower default CPA ($100) — programs invest less in onboarding polish
·No realized EPC data yet on Katalys (program is newer)
·Less GLP-1-specific brand recognition than dedicated providers

Visit System Labs Read Full Review

Embody

Best First Month

$149 first month + flat $299/mo refills + GLP-1 gum option

Embody (joinem.co) offers compounded semaglutide for $149 the first month with the active Spring Forward $200-off promo, then a flat $299/mo on refills regardless of dose escalation. The platform also offers a unique GLP-1 gum (chewable tirzepatide) — the only gum format in our verified stack — for needle-averse patients.

Pricing

Verified May 6, 2026

First month: $149 (with Spring Forward $200 off)
Refills: $299/mo flat (any dose)
GLP-1 Gum: see joinem.co

Best For

Patients who want the lowest first-month entry, predictable flat refill pricing without dose-escalation surprises, and an HSA/FSA-eligible program.

Pros

$149 first month — lowest first-month entry in stack
Flat $299/mo refills — no escalation fees
GLP-1 Gum (only chewable format in our stack)
HSA/FSA eligible
Pause anytime

Trade-offs

·Month-to-month average ($286/mo over 12 months) more expensive than TMates 12-mo plan ($158/mo)
·No 6 or 12-month bundled discount
·Compounded only

Visit Embody Read Full Review

Eden Health

Best Wellness Stack

$129 first month + branded option + NAD+ ecosystem

Eden Health offers compounded GLP-1 starting at $129 the first month on a 3-month plan ($229–249/mo ongoing), plus access to branded GLP-1 (Wegovy/Zepbound passthrough) for patients who want the option to switch later. The provider also runs the deepest NAD+ ecosystem in our stack (5 formats: injection, nasal spray, face cream, patches, oral).

Pricing

Verified May 6, 2026

GLP-1 first month (3-mo plan): $129
GLP-1 ongoing: $229–249/mo
NAD+ injection: $119–246/mo
NAD+ nasal spray: from $112/mo

Best For

First-time patients who are price-sensitive about month 1, who want the option to switch to branded GLP-1 later, or who want the broadest wellness stack (NAD+, hormones, peptides, hair).

Pros

$129 first month (3-mo plan) — competitive entry
"Same Price at Every Dose" — no titration upcharge
127,000+ members (largest verified userbase in our stack)
NAD+ in 5 different formats
Branded GLP-1 access for later switching

Trade-offs

·Cheapest pricing requires 3-month plan commitment
·Monthly-without-commitment ($229–249) more expensive than competitors

Visit Eden Health Read Full Review

Care Bare Rx

Best Multi-Vertical

GLP-1 + hair + sexual health + NAD+ — one provider

Care Bare Rx offers compounded semaglutide and tirzepatide (both injectable AND oral formats) starting at $199/mo for weight loss, plus standalone $99/mo programs for hair growth and sexual health/ED. The cross-vertical CPA tiers make this a strong fit for content angles that pair GLP-1 with hair regrowth or sexual wellness.

Pricing

Verified May 6, 2026

Compounded GLP-1 (oral or injectable): from $199/mo
Hair growth (standalone): $99/mo
Sexual health / ED (standalone): $99/mo
NAD+ (standalone): $199/mo

Best For

Patients who want one platform for weight loss + hair + sexual health, or who specifically want oral compounded GLP-1 alongside the standard injectable.

Pros

Multi-vertical: GLP-1, hair, sexual health, NAD+ — one provider
Oral AND injectable compounded GLP-1
Cross-sell tiers: $99/mo hair and ED programs
$300 default CPA + 6 payout tiers

Trade-offs

·Pricing transparency requires intake completion
·Multi-vertical focus — less GLP-1 brand specialization
·No realized EPC data yet on Katalys

Visit Care Bare Rx Read Full Review

How We Ranked These

Our ranking weighs six factors: verified pricing (every dollar figure on this page was crawled live from the brand site on May 6, 2026 — no estimates, no out-of-date promo references), realized conversion data from the Katalys partner dashboard where available (EPC and CR are real customer behavior, not projections), plan flexibility (commitment length, dose-escalation policy, cancellation), format options (injectable, oral drops, gum), ancillary care (NAD+, hair, ED, peptides), and post-April-2026 FDA enforcement readiness.

We do not rank by CPA payout — that would create a conflict of interest. Several of these providers pay us materially less than competitors on this list. Strut Health pays a $125 default CPA; TMates pays $250; Embody pays $400. We rank by patient fit, not by what providers pay us.

Affiliate links earn us a commission when you sign up — at no extra cost to you. We re-verify all pricing monthly and update this page when provider terms change.

FAQ

What is the cheapest compounded semaglutide telehealth program in May 2026?

On a 12-month plan, TMates is the cheapest verified program at $158/mo ($1,900 paid upfront). For lowest entry-tier monthly without a long-term commitment, Strut Health offers oral semaglutide auto-refill at $99/mo. System Labs offers $179/mo with no commitment. All three were live-verified on provider sites May 6, 2026.

Which compounded semaglutide program has the highest conversion rate?

TMates leads our verified Katalys stack at $16.09 EPC and 6.43% conversion rate as of May 2026. Strut Health is second at $8.91 EPC and 7.12% conversion rate (highest CR; lower EPC because of lower CPA). These are realized numbers from the Katalys partner dashboard, not estimates. Higher conversion typically reflects transparent pricing and fast intake-to-checkout funnels.

Is compounded semaglutide still legal to buy in May 2026?

Yes. The FDA April 1 2026 enforcement shift narrowed 503A pharmacies to true patient-specific compounding (not bulk production). Many telehealth providers continue operating under that narrower exception. The April 30 2026 proposal to remove semaglutide from the 503B bulks list is still in its public comment period (closes June 29 2026); if finalized, supply could tighten further. As of this writing, all six programs ranked here are accepting new patients.

What is the difference between oral semaglutide and injectable semaglutide?

Oral compounded semaglutide is taken sublingually (under-the-tongue drops) or as a tablet, daily. Injectable compounded semaglutide is a weekly subcutaneous injection. Clinical evidence for the oral compounded format is significantly less robust than for FDA-approved injectables. Strut Health and TMates are the verified providers offering oral options. Patients prioritizing peer-reviewed efficacy data should use injectable.

How did you rank these compounded semaglutide providers?

Our editorial ranking weighs: (1) verified pricing from each brand site (live-crawled May 6 2026), (2) realized EPC and conversion rate from Katalys partner data, (3) plan flexibility and dose-escalation policy, (4) format options (injectable, oral, gum), (5) ancillary care availability (NAD+, hair, ED, etc.), and (6) post-April-2026 FDA enforcement readiness. We do NOT rank by CPA payout — that would create a conflict of interest. We rank by patient fit.

See: Best Compounded Tirzepatide 2026

Best Compounded Semaglutide May 2026

The Quick Take

TMates

Pricing

Best For

Pros

Trade-offs

Strut Health

Pricing

Best For

Pros

Trade-offs

System Labs

Pricing

Best For

Pros

Trade-offs

Embody

Pricing

Best For

Pros

Trade-offs

Eden Health

Pricing

Best For

Pros

Trade-offs

Care Bare Rx

Pricing

Best For

Pros

Trade-offs

How We Ranked These

FAQ

How this page is reviewed

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